Thermo Fisher Scientific SKAP2 Polyclonal Antibody

Applications

Western Blot (WB)

• Tested Dilution: 0.5–2 µg/mL

Product Specifications

Product Specific Information

• Predicted to react with bovine, canine, mouse, and rat based on sequence homology.
• Tested in Peptide ELISA: antibody detection limit dilution 1:32,000.

Target Information

Fyb (Fyn binding protein) and the anchoring proteins SKAP55 and SKAP55-R (SKAP55-related protein) associate with the tyrosine kinase p59fyn.
SKAP55 and SKAP55-R bind to Fyb through their SH3 domains and function as substrates for p59Fyn in resting T cells.
SKAP55 contains an N-terminal pleckstrin homology domain and a C-terminal SH3 domain binding motif of adjacent arginine and lysine residues followed by tandem tyrosines (RKxxYxxY).
SKAP55-R, similar in overall structure to SKAP55, contains a coiled-coil N-terminal domain.
SKAP55 associates with SLAP-130, another component of the Fyn complex, which plays a role in regulating signaling events initiated by lymphocyte antigen receptors leading up to T cell activation.
The human SKAP55 gene maps to chromosome 17q21.32 and encodes a 359 amino acid protein.

For Research Use Only.
Not for use in diagnostic procedures. Not for resale without express authorization.