Thermo Fisher Scientific SKAP2 Polyclonal Antibody
SKAP2 단백질을 인식하는 Thermo Fisher Scientific의 염소 유래 폴리클로날 항체. Western blot에 적합하며 인간에 반응. 합성 펩타이드 면역원 사용. 0.5 mg/mL 농도의 액상 형태로 제공되며, -20°C에서 보관.
- 카탈로그번호
- PA518014
- 판매단위
- pk
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Applications
Western Blot (WB)
- Tested Dilution: 0.5–2 µg/mL
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Goat / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide sequence (GLVPKAYIMEMYDI) corresponding to the C-terminus amino acids of SKAP2 (aa 346–359) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.5 mg/mL |
| Purification | Ammonium sulfate precipitation |
| Storage Buffer | TBS, pH 7.3, with 0.5% BSA |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Wet ice |
| RRID | AB_10977144 |
Product Specific Information
- Predicted to react with bovine, canine, mouse, and rat based on sequence homology.
- Tested in Peptide ELISA: antibody detection limit dilution 1:32,000.
Target Information
Fyb (Fyn binding protein) and the anchoring proteins SKAP55 and SKAP55-R (SKAP55-related protein) associate with the tyrosine kinase p59fyn.
SKAP55 and SKAP55-R bind to Fyb through their SH3 domains and function as substrates for p59Fyn in resting T cells.
SKAP55 contains an N-terminal pleckstrin homology domain and a C-terminal SH3 domain binding motif of adjacent arginine and lysine residues followed by tandem tyrosines (RKxxYxxY).
SKAP55-R, similar in overall structure to SKAP55, contains a coiled-coil N-terminal domain.
SKAP55 associates with SLAP-130, another component of the Fyn complex, which plays a role in regulating signaling events initiated by lymphocyte antigen receptors leading up to T cell activation.
The human SKAP55 gene maps to chromosome 17q21.32 and encodes a 359 amino acid protein.
For Research Use Only.
Not for use in diagnostic procedures. Not for resale without express authorization.
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