Thermo Fisher Scientific DCC Monoclonal Antibody (531505)
인간 DCC 단백질을 표적으로 하는 마우스 모노클론 항체로, IHC(P) 실험에 적합합니다. 단백질 A/G로 정제된 동결건조 형태이며, PBS 버퍼에 보존제가 포함되지 않습니다. -20°C에서 보관하며 반복적인 냉동·해동을 피해야 합니다.
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- pk
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Applications
- Immunohistochemistry (Paraffin) (IHC (P)): 8–25 µg/mL
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG2b |
| Class | Monoclonal |
| Type | Antibody |
| Clone | 531505 |
| Immunogen | E. coli-derived recombinant human DCC Ser1323–Phe1447 |
| Conjugate | Unconjugated |
| Form | Lyophilized |
| Purification | Protein A/G |
| Storage buffer | PBS |
| Contains | No Preservative |
| Storage conditions | -20°C, Avoid Freeze/Thaw Cycles |
| RRID | AB_2608776 |
Target Information
This gene encodes a netrin 1 receptor. The transmembrane protein is a member of the immunoglobulin superfamily of cell adhesion molecules and mediates axon guidance of neuronal growth cones toward sources of netrin 1 ligand. The cytoplasmic tail interacts with tyrosine kinases Src and focal adhesion kinase (FAK, also known as PTK2) to mediate axon attraction. The protein partially localizes to lipid rafts and induces apoptosis in the absence of ligand. It functions as a tumor suppressor and is frequently mutated or downregulated in colorectal cancer and esophageal carcinoma.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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