Thermo Fisher Scientific Phospho-Jak2 (Tyr1007, Tyr1008) Recombinant Rabbit Monoclonal Antibody (Jak2Y10071008-PB6)
Recombinant Rabbit Monoclonal Antibody targeting phospho-Jak2 (Tyr1007/1008). Validated for flow cytometry. High specificity for human JAK2. Supplied in liquid form, purified via Protein A/G, stored at -20°C. For research use only.
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Applications
Flow Cytometry (Flow)
- Tested Dilution: 1–1,000 ng/mL
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG, kappa |
| Expression System | HEK293 cells |
| Class | Recombinant Monoclonal |
| Type | Antibody |
| Clone | Jak2Y10071008-PB6 |
| Immunogen | A synthetic phospho-peptide corresponding to residues surrounding Tyr1007/Tyr1008 of human phospho Jak2 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.5 mg/mL |
| Purification | Protein A/G |
| Storage Buffer | PBS with 0.10% BSA, 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2897378 |
Additional Formats
Target Information
Janus kinase 2 (JAK2) is a protein tyrosine kinase involved in specific cytokine receptor signaling pathways and is mutated in polycythemia vera. This kinase contains the catalytic domain (JH1) of JAK2. Activation of JAKs can lead to phosphorylation of STAT (signal transducers and activators of transcription) proteins, which dimerize and translocate to the nucleus to regulate gene transcription, including interferon-stimulated genes.
JAK2 is required for IFN gamma-receptor complex initiation, while JAK1 functions as an amplifier. Mutations affecting JAK2 can cause Budd-Chiari syndrome, Polycythemia vera, Thrombocythemia 3, myelofibrosis, or Acute myelogenous leukemia.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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