Thermo Fisher Scientific TOMM22 Monoclonal Antibody (1C9-2)

Thermo Fisher Scientific TOMM22 Monoclonal Antibody (1C9-2)

Applications and Tested Dilutions

Product Specifications

Product Specific Information

• Recommended positive control: Raji cells
• Store product as a concentrated solution.
• Centrifuge briefly prior to opening the vial.

Target Information

Tom22 has a negatively charged N-terminal region exposed to the cytosol, a putative transmembrane region, and a C-terminal intermembrane space region with little negative charge.
The following functions are assigned to the three domains of Tom22:

1. The cytosolic N-terminal domain plays a dual role, specifically important for presequence binding.
2. The intermembrane space domain provides a trans binding site for presequences.
3. The single membrane anchor of Tom22 is crucial for the integrity of the GIP (general import gene) complex.

The TOM complex of mammalian mitochondria resembles the fungal Tom complex but is distinct from the plant TOM system. Unique components of the mammalian mitochondrial import system (e.g., TOM34 and metaxin) have been identified, while Tom22 and Tom37 have not been identified in plant mitochondria.

For Research Use Only.
Not for use in diagnostic procedures.
Not for resale without express authorization.