Thermo Fisher Scientific HFE2 Polyclonal Antibody
HFE2 단백질을 인식하는 Thermo Fisher Scientific의 Rabbit Polyclonal Antibody입니다. Western blot과 IHC(Paraffin)에서 검증되었으며, 인체 및 다양한 종에 반응합니다. 철 대사 연구 및 juvenile hemochromatosis 관련 연구용으로 적합합니다.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 0.2–2 µg/mL |
| Immunohistochemistry (Paraffin) (IHC (P)) | 5–20 µg/mL |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human, Mouse, Pig, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant Human HJV protein, Gln36–Phe200 (Accession #Q6ZVN8) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.5 mg/mL |
| Purification | Protein A |
| Storage Buffer | PBS, pH 7.4, with 50% glycerol |
| Contains | 0.05% Proclin 300 |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_3094056 |
Target Information
HFE2 is involved in iron metabolism. It may be a component of the signaling pathway which activates hepcidin or act as a modulator of hepcidin expression. It could also represent the cellular receptor for hepcidin. Alternatively spliced transcript variants encoding different isoforms have been identified for this gene.
Defects in this gene cause hemochromatosis type 2A (juvenile hemochromatosis, JH), an early-onset autosomal recessive disorder characterized by severe iron overload resulting in hypogonadotrophic hypogonadism, hepatic fibrosis or cirrhosis, and cardiomyopathy, typically occurring before age 30.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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