Thermo Fisher Scientific KV1.2 (KCNA2) (extracellular) Polyclonal Antibody
Rabbit polyclonal antibody targeting KV1.2 (KCNA2) extracellular domain. Validated for WB and ICC/IF. Lyophilized form, reconstitute in 50 µL water. Suitable for neuroscience and ion channel research. For research use only.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:200–1:1,000 |
| Immunocytochemistry (ICC/IF) | 1:50 |
Product Specifications
| Specification | Description |
|---|---|
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Peptide (C)RDENEDMHGGGVT, corresponding to amino acid residues 189–201 of rat KV1.2 |
| Conjugate | Unconjugated |
| Form | Lyophilized |
| Concentration | 0.8 mg/mL |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2736053 |
Product Specific Information
- Product is shipped at room temperature as a lyophilized powder.
- Store at -20°C upon receipt.
- Reconstitute in 50 µL deionized water before use.
Target Information
Kcna2 (KV1.2) is a voltage-gated potassium channel belonging to the 6-transmembrane (6-TM) family, which also includes Ca²⁺-activated Slo (7-TM) and SK subfamilies. The alpha subunits form tetramers with a single pore-forming region. Potassium channels regulate diverse physiological processes such as:
- Neurotransmitter release
- Heart rate
- Insulin secretion
- Neuronal excitability
- Epithelial electrolyte transport
- Smooth muscle contraction
- Cell volume regulation
The Kcna2 gene encodes a shaker-related subfamily member, containing six membrane-spanning domains with a shaker-type repeat in the fourth segment. It belongs to the delayed rectifier class, aiding efficient nerve cell repolarization after action potentials.
Kcna2 is intronless and clustered with KCNA3 and KCNA10 on chromosome 1.
Diseases associated with KCNA2 include Epileptic Encephalopathy (Early Infantile, 32) and Undetermined Early-Onset Epileptic Encephalopathy.
For Research Use Only. Not for use in diagnostic procedures or resale without authorization.
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