Thermo Fisher Scientific APC10 Polyclonal Antibody
APC10 단백질을 인식하는 Thermo Fisher Scientific의 Rabbit Polyclonal Antibody. 인간, 마우스, 랫트 반응성. WB, IHC, ICC, ELISA 등 다양한 응용 가능. 고순도 Protein A 정제, 안정적 액상 형태로 연구용 적합.
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Thermo Fisher Scientific APC10 Polyclonal Antibody
Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:2,000 |
| Immunohistochemistry (Paraffin) (IHC-P) | 1:50–1:200 |
| Immunohistochemistry (Frozen) (IHC-F) | 1:100–1:500 |
| Immunocytochemistry (ICC/IF) | 1:100–1:500 |
| ELISA | 1:500–1:1,000 |
Product Specifications
| Property | Description |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | KLH conjugated synthetic peptide derived from human APC10 (amino acids 31–130) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A |
| Storage Buffer | 0.01M TBS, pH 7.4, with 50% glycerol, 1% BSA |
| Contains | 0.02% ProClin 300 |
| Storage Conditions | −20°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
Cell cycle regulated protein ubiquitination and degradation within subcellular domains is essential for normal mitosis progression.
APC10 is a highly conserved component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase controlling mitosis and G1 phase progression.
APC/C degrades anaphase inhibitors, mitotic cyclins, and spindle-associated proteins to ensure proper mitotic sequence.
APC/C components are expressed at similar levels across tissues and cell lines, functioning as part of a complex.
APC10 may regulate substrate binding to the APC/C complex, similar to coactivators.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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(이미지 파일: BS-12483R_APC10_Q9UM13-1_Rabbit.svg, BS-12483R_APC10_Q9UM13-1_Rabbit_PDP.jpeg)
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