Thermo Fisher Scientific Thyroglobulin (Thyroidal Cell Marker) Monoclonal Antibody (2H11, 6E1)
인체, 마우스, 랫트 반응성을 가진 갑상선 세포 마커 단클론 항체. IHC 및 Flow Cytometry에 적합하며, Protein A/G로 정제된 액상 형태. Thyroglobulin을 인지하여 갑상선 질환 및 암 연구에 활용 가능.
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Applications
Immunohistochemistry (Paraffin) (IHC (P))
- Tested Dilution: Assay-dependent
Immunohistochemistry (PFA fixed) (IHC (PFA))
- Tested Dilution: 0.1–0.2 µg/mL
Flow Cytometry (Flow)
- Tested Dilution: 0.5–1.0 µg/10^6 cells
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Mouse / IgG1, kappa |
| Class | Monoclonal |
| Type | Antibody |
| Clone | 2H11, 6E1 |
| Immunogen | Human thyroid follicular cells (Thyroglobulin, UniProt ID: P01266-1, antigen range: 1–2768) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A/G |
| Storage Buffer | PBS, pH 7.4 |
| Contains | No preservative |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
Human thyroglobulin (hTg) is a high molecular weight glycoprotein (605 kDa) found in thyroid follicular cells. It plays a central role in the uptake, incorporation, and regulated biosynthesis of thyroid hormones T4 and T3.
Thyroid disorders often have autoimmune origins, and anti-thyroglobulin autoantibodies were the first discovered factor. Anti-hTG is present in all thyroid autoimmune diseases (e.g., Hashimoto thyroiditis, Graves disease) with the highest levels in Hashimoto thyroiditis.
Anti-hTG is also characteristic of thyroid cancer and can be used for patient follow-up studies.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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