Thermo Fisher Scientific SOAT1 Polyclonal Antibody
SOAT1 단백질을 인식하는 Rabbit Polyclonal Antibody로, Western blot과 Immunocytochemistry에 적합합니다. Human, Mouse, Rat 시료에 반응하며, 항원 친화 크로마토그래피로 정제되었습니다. 세포 내 콜레스테롤 대사 연구에 활용 가능합니다.
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Applications and Tested Dilution
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 1:500–1:2,000 | View 1 publication |
| Immunocytochemistry (ICC/IF) | 1:50–1:200 | — |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Published Species | Mouse |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant full length Human SOAT1 (aa 1–550) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.2, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2720633 |
Product Specific Information
The antibody was affinity-purified from rabbit antiserum by affinity chromatography using epitope-specific immunogen. The purity is greater than 95% as determined by SDS-PAGE.
Target Information
SOAT1 (sterol O-acyltransferase-1), also known as ACAT1, is a homotetrameric enzyme that catalyzes the formation of cholesterol esters from cholesterol and long-chain fatty acyl-CoA.
The human SOAT1 gene maps to chromosome 1 and encodes a protein localized in the endoplasmic reticulum (ER) of tissues such as liver, kidney, adrenal glands, and macrophages.
SOAT1 plays a key role in cholesterol homeostasis, foam cell formation, and atherosclerosis progression.
SOAT2 (ACAT2) performs similar functions in lipoprotein assembly and cholesterol esterification in intestinal cells. SOAT2 deficiency is associated with severe mental retardation and hypotonia.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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