Thermo Fisher Scientific SF3A1 Polyclonal Antibody
SF3A1 단백질을 인식하는 Thermo Fisher Scientific의 Rabbit Polyclonal 항체로, Western blot, IHC(P), ICC/IF에 사용 가능. Human에 반응하며 Affinity Chromatography로 정제됨. PBS/sucrose buffer에 보관, -20°C에서 안정적.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 0.2–1 µg/mL |
| Immunohistochemistry (Paraffin) (IHC (P)) | 4–8 µg/mL |
| Immunocytochemistry (ICC/IF) | 4 µg/mL |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide directed towards the N-terminal of human SF3A1 (aa 121–170) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.5 mg/mL |
| Purification | Affinity Chromatography |
| Storage Buffer | PBS with 2% sucrose |
| Contains | 0.09% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Wet ice |
| RRID | AB_2607757 |
Product Specific Information
Peptide sequence:
QQTTQQQLPQ KVQAQVIQET IVPKEPPPEF EFIADPPSIS AFDLDVVKLT
Sequence homology:
Cow: 100%
Dog: 100%
Guinea Pig: 100%
Horse: 100%
Human: 100%
Mouse: 100%
Rabbit: 100%
Rat: 100%
Zebrafish: 86%
Target Information
This gene encodes subunit 1 of the splicing factor 3a protein complex. The splicing factor 3a heterotrimer includes subunits 1, 2, and 3 and is necessary for the in vitro conversion of 15S U2 snRNP into an active 17S particle that performs pre-mRNA splicing.
Subunit 1 belongs to the SURP protein family, named for the SURP motifs that are thought to mediate RNA binding.
Subunit 1 has tandemly repeated SURP motifs in its amino-terminal half, while its carboxy-terminal half contains a proline-rich region and a ubiquitin-like domain.
Binding studies with truncated subunit 1 derivatives demonstrated that the two SURP motifs are necessary for binding to subunit 3, while contacts with subunit 2 may occur through sequences carboxy-terminal to the SURP motifs.
Alternative splicing results in multiple transcript variants encoding different isoforms.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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