Thermo Fisher Scientific SCNN1D Polyclonal Antibody

Applications

Tested Dilution

Publications

Western Blot (WB)

1:1,000-1:2,000

-

ELISA (ELISA)

1 µg/mL

-

Product Specifications

Species Reactivity

Human, Mouse, Rat

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Recombinant fusion protein containing a sequence corresponding to amino acids 540-680 of human SCNN1D (NP_0011238852) if (typeof window.$mangular === undefined || !window.$mangular) { window.$mangular = {}; } $mangular.antigenJson = \[{targetFamily:SCNN1D,uniProtId:P51172-3,ncbiNodeId:9606,antigenRange:540-680,antigenLength:802,antigenImageFileName:PA5-87738_SCNN1D_P51172-3_Rabbit.svg,antigenImageFileNamePDP:PA5-87738_SCNN1D_P51172-3_Rabbit_PDP.jpeg,sortOrder:1}\]; $mangular.isB2BCMGT = false; $mangular.isEpitopesModalImageMultiSizeEnabled = true;

View immunogen .st0{fill:#FFFFFF;} .st1{fill:#1E8AE7;}

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.8 mg/mL

Purification

Affinity Chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20° C, Avoid Freeze/Thaw Cycles

Shipping conditions

Wet ice

RRID

AB_2804377

Product Specific Information

Immunogen sequence: GVEVELLHNT SYTRQACLVS CFQQLMVETC SCGYYLHPLP AGAEYCSSAR HPAWGHCFYR LYQDLETHRL PCTSRCPRPC RESAFKLSTG TSRWPSAKSA GWTLATLGEQ GLPHQSHRQR SSLAKINIVY QELNYRSVEE A; Positive Samples: U-87MG, A-549, MCF-7, Mouse brain, Mouse liver, Rat brain, Rat liver; Cellular Location: Cell membrane, Multi-pass membrane protein

Target Information

SNX6 interacts with members of the transforming growth factor-beta family of receptor serine-threonine kinases. These receptors belong to two classes: type II receptors that bind ligand, and type I receptors that are subsequently recruited to transduce the signal. Of the type II receptors, SNX6 was found to interact strongly with ActRIIB and more moderately with wild type and kinase-defective mutants of TbetaRII. Of the type I receptors, SNX6 was found to interact only with inactivated TbetaRI. SNXs 1-4 also interacted with the transforming growth factor-beta receptor family, showing different receptor preferences. Conversely, SNX6 behaved similarly to the other SNX proteins in its interactions with receptor tyrosine kinases. Strong heteromeric interactions were also seen among SNX1, -2, -4, and -6, suggesting the formation in vivo of oligomeric complexes. These findings are the first evidence for the association of the SNX family of molecules with receptor serine-threonine kinases.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.