Thermo Fisher Scientific SCNN1D Polyclonal Antibody

Applications and Tested Dilution

Product Specifications

Product Specific Information

Immunogen sequence:
GVEVELLHNT SYTRQACLVS CFQQLMVETC SCGYYLHPLP AGAEYCSSAR HPAWGHCFYR LYQDLETHRL PCTSRCPRPC RESAFKLSTG TSRWPSAKSA GWTLATLGEQ GLPHQSHRQR SSLAKINIVY QELNYRSVEE A

Positive Samples:
U-87MG, A-549, MCF-7, Mouse brain, Mouse liver, Rat brain, Rat liver

Cellular Location:
Cell membrane, Multi-pass membrane protein

Target Information

SNX6 interacts with members of the transforming growth factor-beta family of receptor serine-threonine kinases. These receptors belong to two classes: type II receptors that bind ligand, and type I receptors that are subsequently recruited to transduce the signal.
Of the type II receptors, SNX6 interacts strongly with ActRIIB and moderately with wild type and kinase-defective mutants of TbetaRII.
Of the type I receptors, SNX6 interacts only with inactivated TbetaRI. SNXs 1–4 also interact with the transforming growth factor-beta receptor family, showing different receptor preferences.
SNX6 behaves similarly to other SNX proteins in interactions with receptor tyrosine kinases, and strong heteromeric interactions are observed among SNX1, -2, -4, and -6, suggesting the formation of oligomeric complexes in vivo.
These findings provide evidence for the association of the SNX family of molecules with receptor serine-threonine kinases.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.