Thermo Fisher Scientific RhoB Polyclonal Antibody
RhoB 단백질을 인식하는 Thermo Fisher Scientific의 Rabbit Polyclonal Antibody로, WB, IHC, ICC/IF 등 다양한 응용에 적합. 인간, 생쥐, 랫트 반응성. 액상 형태, 1 mg/mL 농도, -20°C 보관. 종양 형성과 세포 신호전달 연구에 활용 가능.
- 카탈로그번호
- PA5115844
- 판매단위
- pk
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Thermo Fisher Scientific RhoB Polyclonal Antibody
Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:1,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:200 |
| Immunocytochemistry (ICC/IF) | 1:100–1:500 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthesized peptide derived from human RHOB (Accession P62745), corresponding to amino acid residues K98–A148 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2900478 |
Product Specific Information
Antibody detects endogenous levels of total RHOB.
Target Information
Rho-related GTP-binding protein (RhoB) mediates apoptosis in neoplastically transformed cells after DNA damage.
It affects cell adhesion and growth factor signaling in transformed cells.
RhoB targets PKN1 to endosomes and is involved in trafficking of the EGF receptor from late endosomes to lysosomes.
It is required for stability and nuclear trafficking of AKT1/AKT, promoting endothelial cell survival during vascular development.
RhoB acts as a tumor suppressor — deletion of RhoB causes tumor formation.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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