Thermo Fisher Scientific Denosumab Monoclonal Antibody (2H7)
인간 RANKL에 특이적인 Denosumab 단일클론 항체로, ELISA 등 연구용 분석에 적합. 동결건조 형태로 안정성이 높으며, 재구성 후에도 장기 보관 가능. Protein A로 정제되어 높은 순도 보장. 연구용으로만 사용 가능.
- 카탈로그번호
- A02101-40
- 판매단위
- pk
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Thermo Fisher Scientific Denosumab Monoclonal Antibody (2H7)
Applications
- ELISA (ELISA)
Tested Dilution: 0.005–0.1 µg/mL
Publications: -
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1, kappa |
| Class | Monoclonal |
| Type | Antibody |
| Clone | 2H7 |
| Immunogen | Denosumab |
| Conjugate | Unconjugated |
| Form | Lyophilized |
| Concentration | 0.5 mg/mL |
| Purification | Protein A |
| Storage Buffer | PBS, pH 7.2 |
| Contains | 0.02% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
Reconstitute the lyophilized powder with deionized water (or equivalent) to a final concentration of 0.5 mg/mL.
The lyophilized product remains stable up to 1 year at -20°C from date of receipt.
Upon reconstitution, it can be stored for 2–3 weeks at 2–8°C or for up to 12 months at -20°C or below.
Avoid repeated freezing and thawing cycles.
Target Information
Denosumab is a fully human IgG2 monoclonal antibody specific to receptor activator of nuclear factor kappa-B ligand (RANKL).
It suppresses bone resorption markers in patients with various metastatic tumors and is under investigation for prevention and treatment of bone metastases.
Chemically, it consists of 2 heavy and 2 light chains. Each light chain has 215 amino acids, and each heavy chain has 448 amino acids with 4 intramolecular disulfides.
FDA approved on June 1, 2010.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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