Thermo Fisher Scientific IL-12 p35 Monoclonal Antibody (27537), PerCP

Applications

• Flow Cytometry (Flow): 10 µL per million cells
• View 4 publications

Product Specifications

Additional Formats

• FITC
• PE
• Request custom conjugation

Product Specific Information

This antibody detects the p35 subunit either as part of a p40/p35 heterodimer or as a free subunit after reduction of the heterodimer.
It does not recognize IL-12 p40 homodimers but shows strong cross-reactivity with p35 subunits from porcine and mouse systems.

Target Information

Interleukin 12A (IL-12A) is a signaling cytokine belonging to the Interleukin-6 protein superfamily.
The IL-12A alpha chain precursor (p35) forms a 35 kDa subunit of the disulfide-linked heterodimeric cytokine IL-12, which exhibits diverse biological activities:

• Acts as a growth factor for activated T and NK cells
• Enhances NK/lymphokine-activated killer cell activity
• Stimulates IFN-γ production in PBMCs
• Promotes differentiation of Th1 and Th2 cells
• Regulates tyrosine phosphorylation of Stat4 protein
• Involved in innate immune signaling requiring nitric oxide synthase 2A
• Forms interleukin-35 (IL-35) with EBI3, contributing to Treg-mediated suppression

For Research Use Only.
Not for use in diagnostic procedures.
Not for resale without express authorization.

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