Thermo Fisher Scientific CAPNS2 Polyclonal Antibody
인간 CAPNS2 단백질을 인식하는 Rabbit Polyclonal 항체로, ICC/IF에 적합합니다. 항원 친화 크로마토그래피로 정제되었으며, PBS와 글리세롤 버퍼에 보존됩니다. 단기 4°C, 장기 -20°C 보관 권장. 연구용 전용 제품입니다.
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Applications
Immunocytochemistry (ICC/IF)
- Tested Dilution: 0.25–2 µg/mL
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant protein corresponding to Human CAPNS2. Recombinant protein control fragment (Product #RP-108284). |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage buffer | PBS, pH 7.2, with 40% glycerol |
| Contains | 0.02% sodium azide |
| Storage conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping conditions | Wet ice |
| RRID | AB_2791585 |
Product Specific Information
Immunogen sequence:
KWQCVYKQYD RDHSGSLGSS QLRGALQAAG FQLNEQLYQM IVRRYANEDG D
Target Information
The Calpain family of proteins are calcium-regulated thiol proteases with broad endopeptidase activity throughout the body.
Calpain small subunit 2 (CSS2 or CAPNS2) is a calcium-dependent protease expressed ubiquitously in the cytoplasm. It forms a heterodimer with a large subunit and catalyzes proteolysis of proteins involved in cytoskeletal remodeling and signal transduction.
CSS2 also acts as a chaperone for the large subunit, maintaining its proper folding and conformation. Upon calcium binding, CSS2 dissociates from the complex, activating the large subunit and relocating to the cell membrane.
Defects in the CSS2 gene can cause abnormal calpain activity and impaired fetal development, indicating its essential role in growth.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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