Thermo Fisher Scientific HnRNP Q Polyclonal Antibody
Thermo Fisher Scientific의 HnRNP Q Polyclonal Antibody는 인간, 마우스, 랫트에 반응하는 Rabbit IgG 항체로, mRNA 처리 및 안정성 관련 연구에 적합합니다. Western blot, IHC, ELISA에 사용 가능하며, 액상 형태로 −20°C에서 보관합니다.
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Applications
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:2,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:200 |
| ELISA | 1 µg/mL |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant fusion protein containing a sequence corresponding to amino acids 1–200 of human hnRNP Q / SYNCRIP (NP_0011531461) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.31 mg/mL |
| Purification | Affinity Chromatography |
| Storage Buffer | PBS, pH 7.3, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | −20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Wet ice |
| RRID | AB_2914651 |
Product Specific Information
Positive test controls include: HeLa, Jurkat, A-431, MCF7, BT-474, Mouse heart, Mouse brain, Rat heart.
The target is usually found in the following locations: Cytoplasm, Endoplasmic reticulum, Microsome, Nucleus, nucleoplasm.
Immunogen sequence:
MATEHVNGNG TEEPMDTTSA VIHSENFQTL LDAGLPQKVA EKLDEIYVAG LVAHSDLDER AIEALKEFNE DGALAVLQQF KDSDLSHVQN KSAFLCGVMK TYRQREKQGT KVADSSKGPD EAKIKALLER TGYTLDVTTG QRKYGGPPPD SVYSGQQPSV GTEIFVGKIP RDLFEDELVP LFEKAGPIWD LRLMMDPLTG
Target Information
Heterogeneous nuclear ribonucleoprotein (hnRNP) Q is implicated in mRNA processing mechanisms. It is a component of the CRD-mediated complex that promotes MYC mRNA stability. Isoforms 1, 2, and 3 are associated with pre-mRNA, splicing intermediates, and mature mRNA complexes.
Isoform 1 binds to apoB mRNA AU-rich sequences and is part of the APOB mRNA editosome complex, potentially modulating posttranscriptional RNA-editing through interactions with A1CF, APOBEC1, or RNA itself.
The protein may participate in translationally coupled mRNA turnover and cytoplasmic mRNA decay mechanisms involving FOS mRNA. Isoform 3 may be involved in vesicle-based mRNA transport via synaptotagmin interactions.
It is also a component of the GAIT (gamma interferon-activated inhibitor of translation) complex, mediating transcript-selective translation inhibition during inflammation by binding GAIT elements in 3'-UTRs of inflammatory mRNAs.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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