Thermo Fisher Scientific GABBR1 Polyclonal Antibody
GABBR1 단백질을 인식하는 Thermo Fisher의 Rabbit Polyclonal Antibody로 신경전달 조절 관련 연구에 적합. Western Blot에 최적화된 항체이며, 다양한 종에서 높은 예측 반응성을 보임. 4°C 단기, -20°C 장기 보관 가능.
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Applications
- Western Blot (WB): 1:500–1:3,000
Product Specifications
| 항목 | 내용 |
|---|---|
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant protein encompassing a sequence within the N-terminus region of mouse GABA B Receptor 1 (exact sequence proprietary) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.42 mg/mL |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2735796 |
Product Specific Information
- Positive Control: Mouse brain, Rat brain
- Predicted Reactivity: Human (99%), Pig (98%), Bovine (97%)
- Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
Target Information
Receptor for GABA. The activity of this receptor is mediated by G-proteins that inhibit adenylyl cyclase activity, stimulate phospholipase A2, activate potassium channels, inactivate voltage-dependent calcium channels, and modulate inositol phospholipid hydrolysis.
Plays a critical role in fine-tuning inhibitory synaptic transmission. Pre-synaptic GABA-B receptors inhibit neurotransmitter release by down-regulating high-voltage activated calcium channels, whereas postsynaptic GABA-B receptors decrease neuronal excitability by activating an inwardly rectifying potassium (Kir) conductance underlying late inhibitory postsynaptic potentials.
Implications include synaptic inhibition, hippocampal long-term potentiation, slow wave sleep, muscle relaxation, and antinociception.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
제품 이미지
(PA5-78507_GABBR1_Q9WV18-1_Rabbit_PDP.jpeg 및 관련 항원 이미지)
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