Thermo Fisher Scientific BTBD12 Polyclonal Antibody
BTBD12 단백질을 인식하는 Thermo Fisher Scientific의 Rabbit Polyclonal Antibody. Western blot, IHC, IP 등 다양한 실험에 사용 가능. 항원 친화 크로마토그래피로 정제된 액상 형태. 인간 시료 반응성, 4°C 보관, 연구용 전용.
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- A302270Ax (2개 옵션)
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Thermo Fisher Scientific BTBD12 Polyclonal Antibody
Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | Assay-dependent |
| Immunohistochemistry (IHC) | 1:500–1:2,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:500–1:2,000 |
| Immunoprecipitation (IP) | 10 µg/mg lysate |
Product Specifications
| Specification | Detail |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Region between residue 1784–1834 of human BTB (POZ) domain containing 12 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | Tris citrate/phosphate, pH 7–8 |
| Contains | 0.09% sodium azide |
| Storage Conditions | 4°C |
| Shipping Conditions | Wet ice |
Product Specific Information
- Recommended shelf life: 1 year from date of receipt
- Application Note: For IHC, epitope retrieval with citrate buffer pH 6.0 is recommended for FFPE tissue sections.
Target Information
This gene encodes a structure-specific endonuclease subunit. The encoded protein contains a central BTB domain and forms a multiprotein complex with ERCC4(XPF)-ERCC1, MUS81-EME1, and SLX1 endonucleases. It also associates with MSH2/MSH3 mismatch repair complex, telomere binding complex TERF2(TRF2)-TERF2IP(RAP1), protein kinase PLK1, and C20orf94.
The complex is required for repair of specific DNA lesions and is critical for cellular responses to replication fork failure. The encoded protein acts as a docking platform for the assembly of multiple structure-specific endonucleases.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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