Thermo Fisher Scientific Desmoglein 3 Recombinant Mouse Monoclonal Antibody (4C2)
Desmoglein 3 단백질을 표적으로 하는 Thermo Fisher의 재조합 마우스 단일클론 항체입니다. ELISA 등 연구용으로 사용 가능하며, 높은 특이성과 친화도를 제공합니다. 액상 형태로 공급되며, -20°C 이하에서 안정적으로 보관할 수 있습니다.
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Thermo Fisher Scientific Desmoglein 3 Recombinant Mouse Monoclonal Antibody (4C2)
Applications
- ELISA (Assay-dependent)
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse |
| Host / Isotype | Mouse / IgG1 |
| Expression System | HEK293 cells |
| Class | Recombinant Monoclonal |
| Type | Antibody |
| Clone | 4C2 |
| Immunogen | Recombinant Human DSG3 protein |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.4, with 50% glycerol |
| Contains | 0.03% Proclin 300 |
| Storage Conditions | -20°C or -80°C if preferred |
| Shipping Conditions | Wet ice |
| RRID | AB_3093856 |
Target Information
Desmoglein 3 (Dsg3), also known as Cadherin family member 6 (CDHF6), is a member of the desmosomal cadherin family and plays a critical role in cell-cell adhesion. It is predominantly expressed in stratified squamous epithelium, including the skin, oral mucosa, and esophagus. Desmoglein 3 has been characterized as the auto-antigen of pemphigus vulgaris (PV), a life-threatening autoimmune disease. Binding of anti-Desmoglein 3 autoantibodies causes the loss of cell-cell adhesion, which clinically manifests as blisters on the skin and oral mucosa, and histologically as suprabasilar acantholysis.
주의 사항
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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