Thermo Fisher Scientific SIK2 Polyclonal Antibody
Rabbit 폴리클로날 항체로 인간 SIK2 단백질(600–650aa)을 인식. Western blot 및 Immunoprecipitation에 적합. 액상 형태, 1 mg/mL 농도, 4°C 보관. 연구용으로만 사용 가능.
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Applications
Western Blot (WB)
- Tested Dilution: 1:2,000–1:10,000
Immunoprecipitation (IP)
- Tested Dilution: 2–5 µg/mg lysate
Product Specifications
| 항목 | 내용 |
|---|---|
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Region between residue 600 and 650 of Human salt‑inducible kinase 2 (SIK2) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Storage Conditions | 4°C |
| Shipping Conditions | Wet ice |
Product Specific Information
- Recommended shelf life: 1 year from date of receipt
- Based on 100% sequence identity, this antibody is predicted to react with Orangutan
Target Information
SNF1LK2 (QIK) is a serine/threonine kinase and a salt‑inducible kinase belonging to the AMP‑activated protein kinase family.
It negatively regulates CRE‑binding protein (CREB) activity by phosphorylating the CREB‑specific coactivator TORC.
SIK2 is part of a signaling cascade regulating insulin‑induced genes PGC‑1α and UCP‑1 in brown adipocytes, with implications in obesity and insulin resistance.
It also acts as a key regulator for neuronal survival after ischemia, suppressing CREB‑mediated gene expression following oxygen‑glucose deprivation.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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