Thermo Fisher Scientific MMP2 Polyclonal Antibody

Applications and Tested Dilutions

Product Specifications

Target Information

Matrix metalloproteinases (MMPs) are proteolytic enzymes capable of degrading connective tissue components. They share a conserved metal-binding active site and are inhibited by tissue inhibitors of metalloproteinases (TIMPs). MMP2 is synthesized as a 631 amino acid proenzyme, activated by cleavage of the first 80 amino acids, and contains propeptide, catalytic, and hemopexin domains.
MMPs collectively degrade extracellular matrix components such as collagens, fibronectin, laminin, and basement membrane glycoproteins. MMP2 plays a crucial role in tissue remodeling, and mutations in the MMP2 gene are associated with Winchester syndrome and Nodulosis-Arthropathy-Osteolysis (NAO) syndrome. Two transcript variants encoding different isoforms of MMP2 have been identified.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.