Thermo Fisher Scientific PPP1R3B Polyclonal Antibody

Applications

• Western Blot (WB): 1:500–1:3,000

Product Specifications

Product Specific Information

• Keep as concentrated solution.
• Predicted reactivity: Mouse (82%), Rat (87%), Bovine (85%).
• Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.

Target Information

Acts as a glycogen-targeting subunit for phosphatase PP1. Facilitates interaction of PP1 with enzymes of glycogen metabolism and regulates its activity. Suppresses the rate at which PP1 dephosphorylates (inactivates) glycogen phosphorylase and enhances the rate at which it activates glycogen synthase, thereby limiting glycogen breakdown. Its activity is inhibited by PYGL, resulting in inhibition of the glycogen synthase and glycogen phosphorylase phosphatase activities of PP1. Overexpression in hepatocytes dramatically increases basal and insulin-stimulated glycogen synthesis.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.