Thermo Fisher Scientific FOXO4 Monoclonal Antibody (OTI8F1), TrueMAB
FOXO4 단백질을 인식하는 마우스 단클론 항체로, Western blot에 적합합니다. Human, Mouse, Rat에 반응하며, 동결건조 형태로 제공됩니다. 고순도 친화 크로마토그래피 정제, PBS buffer에 trehalose 포함. 연구용으로만 사용 가능합니다.
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Applications
- Western Blot (WB): 1:2,000 dilution tested
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Mouse / IgG2a |
| Class | Monoclonal |
| Type | Antibody |
| Clone | OTI8F1 |
| Immunogen | Human recombinant protein fragment corresponding to amino acids 206–505 of human FOXO4 produced in E. coli |
| Conjugate | Unconjugated |
| Form | Lyophilized |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage buffer | PBS, pH 7.3, with 8% trehalose |
| Contains | No preservative |
| Storage conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
For reconstitution, add 100 µL distilled water to achieve a final antibody concentration of approximately 1 mg/mL.
For conjugation experiments, perform an additional desalting step (e.g., Zeba Spin Desalting Columns, 7K MWCO, 0.5 mL, Product #89882).
Target Information
FOXO4 (Forkhead box O4) is encoded by the FOXO4 gene located on the X chromosome. It is also known as AFX1 or MLLT7 and belongs to the O class of forkhead/winged helix transcription factors, along with FOXO1, FOXO3, and FOXO6.
FOXO4 is highly expressed in skeletal muscle and adipose tissue. It binds to the Insulin Responsive Element (IRE) and activates downstream targets of Insulin/IGF1 signaling such as IGFBP1. Phosphorylation by Akt leads to FOXO4 binding to 14-3-3 proteins and its translocation out of the nucleus.
For Research Use Only. Not for use in diagnostic procedures or resale without authorization.
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