Thermo Fisher Scientific CD31 Polyclonal Antibody
CD31(PECAM-1)에 특이적인 Rabbit Polyclonal Antibody로, 인간 및 다양한 종에서 반응성을 보입니다. Western blot, IHC 등 여러 응용에 적합하며 항원 친화 크로마토그래피로 정제되었습니다. 액상 형태로 4°C에서 보관하며 연구용으로만 사용됩니다.
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- PA516301
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- pk
카탈로그
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Applications and Tested Dilutions
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 1:500 | View 5 publications |
| Immunohistochemistry (IHC) | - | View 24 publications |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50 | View 3 publications |
| Immunohistochemistry (PFA fixed) (IHC (PFA)) | - | View 1 publication |
| Immunohistochemistry (Frozen) (IHC (F)) | - | View 1 publication |
| Immunocytochemistry (ICC/IF) | - | View 10 publications |
| Miscellaneous PubMed (Misc) | - | View 2 publications |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human |
| Published Species | Dog, Hamster, Human, Mouse, Pig, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide corresponding to mouse CD31, aa 700 to the C-terminus |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.013 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.2, with 1% BSA |
| Contains | 0.1% sodium azide |
| Storage Conditions | 4°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_10981955 |
Product Specific Information
Recommended Positive Controls:
- IHC (P): Mouse skin and xenograft tissue, human tonsil tissue
- WB: Jurkat whole cell lysate, human vascular endothelial cell lysate
- IHC (F): Human fetal heart tissue
Target Information
CD31 (platelet endothelial cell adhesion molecule-1, PECAM-1) is an inhibitory coreceptor involved in regulation of T cell and B cell signaling through dual immunoreceptor tyrosine-based inhibitory motifs (ITIMs). Upon phosphorylation by associated kinases, these motifs provide docking sites for protein-tyrosine phosphatases.
CD31 is expressed ubiquitously within the vascular compartment and primarily located at junctions between adjacent cells. Its N-terminal Ig-like domain mediates homophilic binding, playing a key role in cell-cell interactions.
CD31 functions in integrin-mediated adhesion, transendothelial migration, angiogenesis, apoptosis, negative regulation of immunoreceptor signaling, autoimmunity, macrophage phagocytosis, IgE-mediated anaphylaxis, and thrombosis. It is a key regulatory molecule in the vascular system.
For Research Use Only.
Not for use in diagnostic procedures.
Not for resale without express authorization.
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