Thermo Fisher Scientific CD31 Polyclonal Antibody
CD31(PECAM-1)에 특이적인 Rabbit Polyclonal Antibody로, 인간 및 다양한 종에서 반응성을 보입니다. Western blot, IHC 등 여러 응용에 적합하며 항원 친화 크로마토그래피로 정제되었습니다. 액상 형태로 4°C에서 보관하며 연구용으로만 사용됩니다.
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Applications and Tested Dilutions
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 1:500 | View 5 publications |
| Immunohistochemistry (IHC) | - | View 24 publications |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50 | View 3 publications |
| Immunohistochemistry (PFA fixed) (IHC (PFA)) | - | View 1 publication |
| Immunohistochemistry (Frozen) (IHC (F)) | - | View 1 publication |
| Immunocytochemistry (ICC/IF) | - | View 10 publications |
| Miscellaneous PubMed (Misc) | - | View 2 publications |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human |
| Published Species | Dog, Hamster, Human, Mouse, Pig, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide corresponding to mouse CD31, aa 700 to the C-terminus |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.013 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.2, with 1% BSA |
| Contains | 0.1% sodium azide |
| Storage Conditions | 4°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_10981955 |
Product Specific Information
Recommended Positive Controls:
- IHC (P): Mouse skin and xenograft tissue, human tonsil tissue
- WB: Jurkat whole cell lysate, human vascular endothelial cell lysate
- IHC (F): Human fetal heart tissue
Target Information
CD31 (platelet endothelial cell adhesion molecule-1, PECAM-1) is an inhibitory coreceptor involved in regulation of T cell and B cell signaling through dual immunoreceptor tyrosine-based inhibitory motifs (ITIMs). Upon phosphorylation by associated kinases, these motifs provide docking sites for protein-tyrosine phosphatases.
CD31 is expressed ubiquitously within the vascular compartment and primarily located at junctions between adjacent cells. Its N-terminal Ig-like domain mediates homophilic binding, playing a key role in cell-cell interactions.
CD31 functions in integrin-mediated adhesion, transendothelial migration, angiogenesis, apoptosis, negative regulation of immunoreceptor signaling, autoimmunity, macrophage phagocytosis, IgE-mediated anaphylaxis, and thrombosis. It is a key regulatory molecule in the vascular system.
For Research Use Only.
Not for use in diagnostic procedures.
Not for resale without express authorization.
제품 이미지
(원본 항원 구조 이미지 등은 하단에 유지됩니다.)
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