Thermo Fisher Scientific MLNR Polyclonal Antibody
Thermo Fisher Scientific의 MLNR Polyclonal Antibody는 인간 MLNR 단백질을 인식하는 토끼 폴리클로날 항체입니다. Western blot과 ICC/IF에 적합하며, 고순도 친화 크로마토그래피로 정제되었습니다. PBS/glycerol 버퍼에 보관되며 연구용으로만 사용됩니다.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:1,000 |
| Immunocytochemistry (ICC/IF) | 1:100–1:500 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthesized peptide derived from human MLNR (Accession O43193), corresponding to amino acid residues I350–G400 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.4, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2854511 |
Product Specific Information
Antibody detects endogenous levels of total MTLR.
Target Information
Motilin is a conserved 22-amino acid peptide hormone secreted from enterochromaffin cells of the gastrointestinal tract. It enhances intestinal motility by inducing duodenal contractions and binding to surface receptors designated as GPR38 (G-protein coupled receptor 38).
Motilin receptors are primarily expressed in the stomach, thyroid, and bone marrow, and are related to other G-protein coupled receptors in the pituitary and hypothalamus that mediate growth hormone secretagogue signaling.
The gene encoding GPR38 is alternatively spliced to produce two isoforms, GPR38-A and GPR38-B. GPR38-A contains seven transmembrane domains, while GPR38-B is predicted to contain five. Consistent with other G-protein coupled receptors, GPR38 activates phospholipase C signaling pathways and induces intracellular calcium mobilization upon motilin binding.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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