Thermo Fisher Scientific RelB Polyclonal Antibody

Applications

Tested Application

• Western Blot (WB)

Recommended Dilution

• 0.2–1 µg/mL

Product Specifications

Product Specific Information

• Peptide sequence: LRSGPASGPS VPTGRAMPSR RVARPPAAPE LGALGSPDLS SLSLAVSRST
• Sequence homology:
  • Dog: 100%
  • Guinea Pig: 86%
  • Human: 100%

Target Information

The NFκB transcription factor was originally identified as a protein complex consisting of a DNA-binding subunit and an associated protein. The DNA-binding subunit is functionally related to c-Rel p75 and Rel B p68. The p50 subunit was initially believed to be a functionally unique protein derived from the amino-terminus of a precursor designated p105. A second protein designated p52 (previously referred to as p49) has been identified that can act as an alternative NFκB subunit. Rel B does not bind with high affinity to NFκB sites, but heterodimers between Rel B and p50 bind with an affinity comparable to that of p50 NFκB homodimers. However, Rel B/p50 heterodimers, in contrast to NFκB heterodimers, transactivate transcription of promoters containing κB binding sites.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.