Thermo Fisher Scientific NT5E Monoclonal Antibody (OTI1G2), TrueMAB
Human CD73 (NT5E) 단백질을 인식하는 mouse monoclonal antibody로 Western blot과 IHC(Paraffin)에 적합. TrueMAB 포맷으로 높은 특이성과 재현성을 제공하며, 액상 형태로 -20°C에서 보관. 연구용으로만 사용 가능.
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Applications
Western Blot (WB)
- Tested Dilution: 1:2,000
Immunohistochemistry (Paraffin) (IHC (P))
- Tested Dilution: 1:150
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | OTI1G2 |
| Immunogen | Human recombinant protein fragment corresponding to amino acids 119–232 of human NT5E produced in E. coli |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS with 1% BSA, 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
CD73 (Ecto-5'-nucleotidase, 5'-ribonucleotide phosphohydrolase) catalyzes the conversion of purine 5'-mononucleotides to nucleosides at neutral pH, with AMP as the preferred substrate.
It forms a dimer of two identical 70 kDa subunits anchored to the plasma membrane via a glycosyl phosphatidylinositol linkage.
CD73 serves as a marker for lymphocyte differentiation, and deficiencies are associated with various immunodeficiency diseases.
Other 5'-nucleotidases differ by substrate affinity, magnesium ion requirement, ATP activation, and phosphate inhibition.
The CD73 gene is localized to chromosome 6q14–q21. Mutations can cause joint and arterial calcification and intestinal tuberculosis.
Two transcript variants encoding different isoforms of CD73 have been identified.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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