Thermo Fisher Scientific PDE6B Polyclonal Antibody

Applications

Immunohistochemistry (Paraffin) (IHC (P))

• Tested Dilution: 1:500–1:1,000

Immunocytochemistry (ICC/IF)

• Tested Dilution: 0.25–2 µg/mL

Product Specifications

Product Specific Information

• Immunogen sequence:
  MSLSEEQARSF LDQNPDFARQ YFGKKLSPEN VAAACEDGCP PDCDSLRDLC QVEEST
• Highest antigen sequence identity to the following orthologs:
  Mouse 81%, Rat 79%

Target Information

The second messengers cAMP and cGMP are key regulatory molecules involved in various signal transduction pathways. Their levels are controlled by synthesis via nucleotide cyclases and hydrolysis by cyclic nucleotide phosphodiesterases (PDEs).
PDE6 functions as the effector enzyme in the G protein-mediated visual signal transduction cascade. It includes rod and cone specific catalytic subunits (α’, α, β), an inhibitory γ subunit, and a δ subunit of unknown function.
The catalytic core consists of α’/α’ homodimers (cone) and α/β heterodimers (rod). The C-terminus of both catalytic and inhibitory subunits undergoes methylation, myristoylation, and prenylation, essential for proper complex assembly and membrane association.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.