Thermo Fisher Scientific ADAM10 Monoclonal Antibody (6C3C7)
ADAM10 단백질을 인식하는 Mouse monoclonal antibody로, Western blot, IHC, Flow Cytometry에 적합합니다. 단백질 G로 정제된 액상형 항체이며, 인간 시료에 반응합니다. 단기 4°C, 장기 -20°C 보관 권장.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:2,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:200–1:1,000 |
| Flow Cytometry (Flow) | 1:200–1:400 |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | 6C3C7 |
| Immunogen | Purified recombinant fragment of human ADAM10 (aa: EXTRA(20–119)) expressed in E. coli |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein G |
| Storage Buffer | PBS |
| Contains | 0.05% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2898353 |
Product Specific Information
This antibody has been tested in indirect ELISA.
Target Information
Proinflammatory cytokine tumor necrosis factor-alpha (TNF-α) contributes to inflammatory responses and programmed cell death. The Notch receptor and its ligand participate in cell fate decisions during vertebrate development and are associated with several human disorders, including T-cell lymphoma. TNF-α, Notch, and its ligand Delta are membrane-bound molecules that are cleaved by proteases to release mature or functional proteins. ADAM10, a metalloprotease-disintegrin in the mammalian ADAM family, was identified to cleave TNF-α, Notch, and Delta. Genes encoding human, mouse, and bovine ADAM10 were cloned and designated ADAM10, kuzbanian (KUZ), and MADM, respectively. ADAM10 mRNA is expressed in various human and bovine tissues.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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