Thermo Fisher Scientific SHP-1 Polyclonal Antibody
SHP-1 단백질을 인식하는 Rabbit Polyclonal Antibody로, Human, Mouse, Rat 시료에 반응합니다. WB, IHC, ICC, Flow Cytometry 등 다양한 응용 가능. Protein A로 정제된 액상 형태이며, 장기 보관 시 -20°C에서 안정적입니다.
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Thermo Fisher Scientific SHP-1 Polyclonal Antibody
Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:1,000–1:2,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:200 |
| Immunocytochemistry (ICC/IF) | 1:50–1:200 |
| Flow Cytometry (Flow) | 1:50–1:200 |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant protein within C-terminal Human SHP-1 aa 550–595 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A |
| Storage Buffer | PBS, pH 7.4, with 40% Glycerol, 0.2% BSA |
| Contains | 0.05% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2802832 |
Target Information
SHP-1 (PTPN6) is a non-receptor protein tyrosine phosphatase primarily expressed in hematopoietic cells. It contains two SH2 domains, a tyrosine phosphatase catalytic domain, and a carboxy-terminal regulatory domain. SHP-1 downregulates several tyrosine kinase-regulated pathways by dephosphorylating target proteins.
In hematopoietic cells, the amino-terminal SH2 domain binds to tyrosine-phosphorylated erythropoietin receptors (EpoR) to negatively regulate hematopoietic growth. Overexpression in epithelial cells leads to dephosphorylation of the Ros receptor tyrosine kinase and suppression of Ros-dependent cell proliferation and transformation.
In myeloid cells, SHP-1 associates with the IL-3R beta chain following ligand binding and downregulates IL-3-induced tyrosine phosphorylation and cell proliferation.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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