Thermo Fisher Scientific HERPUD1 Polyclonal Antibody

Applications

Tested Dilution

Publications

Western Blot (WB)

0.04-0.4 µg/mL

-

Immunohistochemistry (Paraffin) (IHC (P))

1:500-1:1,000

-

Product Specifications

Species Reactivity

Human

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Recombinant protein corresponding to Human HERPUD1. Recombinant protein control fragment (Product #RP-98600). if (typeof window.$mangular === undefined || !window.$mangular) { window.$mangular = {}; } $mangular.antigenJson = \[{targetFamily:HERPUD1,uniProtId:Q15011-1,ncbiNodeId:9606,antigenRange:22-132,antigenLength:391,antigenImageFileName:PA5-59282_HERPUD1_Q15011-1_Rabbit.svg,antigenImageFileNamePDP:PA5-59282_HERPUD1_Q15011-1_Rabbit_PDP.jpeg,sortOrder:1}\]; $mangular.isB2BCMGT = false; $mangular.isEpitopesModalImageMultiSizeEnabled = true;

View immunogen .st0{fill:#FFFFFF;} .st1{fill:#1E8AE7;}

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.4 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.2, with 40% glycerol

Contains

0.02% sodium azide

Storage conditions

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

Shipping conditions

Wet ice

RRID

AB_2642399

Product Specific Information

Immunogen sequence: RDLELSGDRG WSVGHLKAHL SRVYPERPRP EDQRLIYSGK LLLDHQCLRD LLPKQEKRHV LHLVCNVKSP SKMPEINAKV AESTEEPAGS NRGQYPEDSS SDGLRQREVL R

Highest antigen sequence identity to the following orthologs: Mouse - 86%, Rat - 84%.

Target Information

The accumulation of unfolded proteins in the endoplasmic reticulum (ER) triggers the ER stress response. This response includes the inhibition of translation to prevent further accumulation of unfolded proteins, the increased expression of proteins involved in polypeptide folding, known as the unfolded protein response (UPR), and the destruction of misfolded proteins by the ER-associated protein degradation (ERAD) system. This gene may play a role in both UPR and ERAD. Its expression is induced by UPR and it has an ER stress response element in its promoter region while the encoded protein has an N-terminal ubiquitin-like domain which may interact with the ERAD system. This protein has been shown to interact with presenilin proteins and to increase the level of amyloid-beta protein following its overexpression. Alternative splicing of this gene produces multiple transcript variants, some encoding different isoforms. The full-length nature of all transcript variants has not been determined.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.