Thermo Fisher Scientific HERPUD1 Polyclonal Antibody
HERPUD1 단백질을 인식하는 Rabbit Polyclonal 항체로, Western blot 및 IHC(P) 실험에 적합합니다. 항원 친화 크로마토그래피로 정제되었으며, PBS/glycerol buffer에 보존됩니다. 인간 HERPUD1에 반응하며, UPR 및 ERAD 연구에 유용합니다.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 0.04–0.4 µg/mL |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:500–1:1,000 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant protein corresponding to Human HERPUD1. Recombinant protein control fragment (Product # RP-98600) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.4 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.2, with 40% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2642399 |
Product Specific Information
Immunogen sequence:
RDLELSGDRG WSVGHLKAHL SRVYPERPRP EDQRLIYSGK LLLDHQCLRD LLPKQEKRHV LHLVCNVKSP SKMPEINAKV AESTEEPAGS NRGQYPEDSS SDGLRQREVL R
Sequence identity (orthologs):
- Mouse: 86%
- Rat: 84%
Target Information
The accumulation of unfolded proteins in the endoplasmic reticulum (ER) triggers the ER stress response. This includes inhibition of translation to prevent further accumulation of unfolded proteins, increased expression of folding-related proteins (UPR), and degradation of misfolded proteins via the ER-associated degradation (ERAD) system.
HERPUD1 may play a role in both UPR and ERAD. Its expression is induced by UPR, and it contains an ER stress response element in its promoter. The encoded protein has an N-terminal ubiquitin-like domain that may interact with the ERAD system and has been shown to interact with presenilin proteins, increasing amyloid-beta levels upon overexpression.
Alternative splicing produces multiple transcript variants, though their full-length nature is not fully determined.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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