Thermo Fisher Scientific GPR17 Monoclonal Antibody (OTI17C1), TrueMAB
GPR17 단백질을 인식하는 Mouse monoclonal antibody로, Western blot 및 IHC(P) 응용에 적합합니다. Human, Mouse, Rat 종에 반응하며, Lyophilized 형태로 제공됩니다. 연구용으로만 사용되며, 고순도 Affinity chromatography로 정제되었습니다.
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Thermo Fisher Scientific GPR17 Monoclonal Antibody (OTI17C1), TrueMAB
Applications
- Western Blot (WB): Assay-dependent
- Immunohistochemistry (Paraffin) (IHC (P)): 1:150–1:600
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Mouse / IgG2b |
| Class | Monoclonal |
| Type | Antibody |
| Clone | OTI17C1 |
| Immunogen | Synthetic peptide within Human GPR17 C-terminal (sequence proprietary) |
| Conjugate | Unconjugated |
| Form | Lyophilized |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.3, with 8% trehalose |
| Contains | No preservative |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
For reconstitution, add 100 µL distilled water to achieve a final antibody concentration of approximately 1 mg/mL.
For conjugation experiments, perform an additional desalting step using Zeba Spin Desalting Columns, 7K MWCO, 0.5 mL (Product #89882).
Target Information
The G-protein-coupled receptor (GPCR) superfamily includes 600–1,000 members and represents the largest class of molecular targets with therapeutic relevance.
GPR17 is an orphan GPCR involved in oligodendrocyte differentiation and myelination in the CNS. It is expressed in brain, kidney, heart, and umbilical vein endothelial cells.
GPR17 has dual specificity for uracil nucleotides and cysteinyl leukotrienes, signaling through G(i) and inhibiting adenylyl cyclase. It may mediate brain damage following ischemia.
For Research Use Only. Not for use in diagnostic procedures or resale without express authorization.
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