Thermo Fisher Scientific PIGR Recombinant Rabbit Monoclonal Antibody (40)

Applications

• ELISA (ELISA)
  Tested Dilution: 1:5,000–1:10,000

Product Specifications

Product Specific Information

This product is preservative-free. It is recommended to add sodium azide (final concentration 0.05%–0.1%) to prevent contamination.

Recombinant rabbit monoclonal antibodies are produced using in vitro expression systems developed by cloning specific antibody DNA sequences from immunoreactive rabbits. Individual clones are screened to select the best candidates for production.

Advantages of recombinant rabbit monoclonal antibodies:

• High specificity and sensitivity
• Lot-to-lot consistency
• Animal origin-free formulations
• Broader immunoreactivity due to larger rabbit immune repertoire

This antibody has specificity for Mouse PIGR / Poly-Ig Receptor.

Target Information

Polymeric IgA and IgM are produced and secreted by B cells in the lamina propria, beneath the mucosal lining of polarized epithelial cells. Polymeric immunoglobulin receptors (pIgRs) are expressed on the basolateral surface of glandular epithelia and mediate transcellular transport of secretory immunoglobulin polymers across the epithelium.

During this process, pIgR undergoes proteolytic cleavage to generate the secretory component (SC). When immunoglobulin polymers associate with SC, they become resistant to enzymatic degradation. SC and pIgR are crucial for mucosal immunity, serving as molecular chaperones for polymeric Igs to remain intact and functional.

The human SC (pIgR) gene maps to chromosome 1q31–q41 and encodes a 764 amino acid protein containing five immunoglobulin-like units and a transmembrane region homologous to certain immunoglobulin variable regions.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.