Thermo Fisher Scientific CYP3A5 Polyclonal Antibody

Applications

Western Blot (WB)

• Tested Dilution: 0.2–1 µg/mL

Immunohistochemistry (Paraffin) (IHC (P))

• Tested Dilution: 1:600

Product Specifications

Product Specific Information

• Immunogen sequence:
  AITDPDVIRT VLVKECYSVF TNRRSLGPVG FMKSAISLAE DEEWKRIRSL

• Storage recommendations:
  For short term use, store at 2–8°C up to 1 week.
  For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

• Predicted homology:
  Cow: 79%
  Dog: 91%
  Guinea Pig: 92%
  Horse: 86%
  Human: 100%
  Mouse: 82%
  Pig: 93%
  Rat: 79%
  Sheep: 79%

Target Information

CYP3A5 is a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases that catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids, and other lipids. This protein localizes to the endoplasmic reticulum and its expression is induced by glucocorticoids and some pharmacological agents. The enzyme metabolizes drugs such as nifedipine and cyclosporine, as well as steroid hormones including testosterone, progesterone, and androstenedione.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.