Thermo Fisher Scientific CD27 (Tumor Necrosis Factor Receptor Superfamily 7) Monoclonal Antibody (LPFS2/1611)

Applications and Tested Dilution

Product Specifications

Target Information

CD27 is a 50 kDa member of the tumor necrosis factor (TNF) receptor superfamily that includes CD40 and CD30. Members of this family regulate cell proliferation and death. Unlike other TNFR/TNF family members, CD27 and its ligand CD70 are primarily expressed on lymphocytes. Proper antigen receptor ligation induces high CD27 expression, while CD70 expression requires additional co-stimulatory or pro-inflammatory signals.

CD27 exists as a disulfide-linked homodimer on mature thymocytes, peripheral blood T cells, and a subset of B cells. Activation of T cells via the TCR-CD3 complex upregulates CD27 on the plasma membrane and releases a soluble 28–32 kDa form (sCD27), detectable in plasma, urine, or spinal fluid. Soluble CD27 serves as a prognostic marker in acute and chronic B cell malignancies.

RgpA, a cysteine proteinase, activates T cells through protease-activated receptors (PARs) but degrades CD27, counteracting CD27/CD70-mediated activation. CD27-binding protein (SIVA), a proapoptotic protein, interacts with CD27 and plays a role in apoptosis induced by this receptor. Diseases associated with CD27 dysfunction include Lymphoproliferative Syndrome 2 and Autosomal Recessive Lymphoproliferative Syndrome.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.