Thermo Fisher Scientific MYPT1 Polyclonal Antibody
MYPT1 단백질을 인식하는 Rabbit Polyclonal Antibody로, Western blot과 IHC(P)에서 사용 가능. 비포스포펩타이드 항원을 기반으로 제작되었으며, 1 mg/mL 농도의 액상 형태로 제공. -20°C 보관, Wet ice 운송 조건.
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Applications
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:1,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:100 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthetic non-phosphopeptide derived from human MYPT1 around the phosphorylation site of Thr696 (R-S-TP-Q-G) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Storage conditions | -20°C |
| Shipping conditions | Wet ice |
| RRID | AB_2554899 |
Target Information
Myosin phosphatase target subunit 1 (MYPT1), also known as the myosin-binding subunit of myosin phosphatase, is a regulatory subunit that modulates the interaction between actin and myosin downstream of the Rho GTPase pathway.
RhoA in its active GTP-bound form interacts with the myosin-binding subunit (MBS) to regulate myosin light chain (MLC) phosphorylation, influencing smooth muscle contraction and actin-myosin interactions in nonmuscle cells.
Rho-associated kinase (Rho-kinase), activated by GTP-RhoA, phosphorylates MBS, leading to inactivation of myosin phosphatase. Overexpression of RhoA or its active form increases phosphorylation of both MBS and MLC, indicating that Rho inhibits myosin phosphatase through Rho-kinase activity.
Multiple transcript variants encoding different isoforms of MYPT1 have been identified.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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