Thermo Fisher Scientific PD L1 (CD274) Monoclonal Antibody (OTI2F5)
PD-L1(CD274) 단백질을 인식하는 Mouse IgG1 단클론 항체로 인간 시료에 반응합니다. Western blot과 Flow cytometry에 최적화되어 있으며, 액상 형태로 1 mg/mL 농도 제공합니다. 종양 면역 회피 연구 및 PD-1/PD-L1 경로 분석에 적합합니다.
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Applications
Western Blot (WB)
- Tested Dilution: 1:500
Flow Cytometry (Flow)
- Tested Dilution: 1:100
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | OTI2F5 |
| Immunogen | Full-length human recombinant protein of human CD274 (NP_054862) produced in HEK293T cells |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS with 1% BSA, 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
Programmed death receptor ligand 1 (PD-L1, also called B7-H1) is a recently described B7 family member. To date, one specific receptor has been identified that can be ligated by PD-L1. This receptor, programmed death receptor 1 (PD-1), negatively regulates T-cell receptor (TCR) signaling. Upon ligating its receptor, PD-L1 has been reported to decrease TCR-mediated proliferation and cytokine production. PD-L1 expression is abundant on many murine and human cancers and can be further up-regulated upon IFN-gamma stimulation. Thus, PD-L1 might play an important role in tumor immune evasion.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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