Thermo Fisher Scientific STK4 Monoclonal Antibody (4F4)
STK4(MST1) 단백질을 인식하는 Mouse monoclonal antibody(클론 4F4). Western blot, ICC/IF, ELISA, in situ PLA 등에 적합. 인간, 마우스, 랫트 반응성. Affinity chromatography로 정제된 액상 형태, PBS buffer에 보존.
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Applications
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1–5 µg/mL |
| Immunocytochemistry (ICC/IF) | 25 µg/mL |
| ELISA | 0.1 ng/mL |
| in situ PLA (PLA) | 1:1200 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Mouse / IgG2a, kappa |
| Class | Monoclonal |
| Type | Antibody |
| Clone | 4F4 |
| Immunogen | STK4 (NP_006273, 391–485 a.a.) partial recombinant protein with GST tag (GST tag MW: 26 kDa) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | See Label |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.4 |
| Contains | No preservative |
| Storage Conditions | −20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
Sequence of this protein is as follows:
AKPSFLEYFE QKEKENQINS FGKSVPGPLK NSSDWKIPQD GDYEFLKSWT VEDLQKRLLA LDPMMEQEIE EIRQKYQSKR QPILDAIEAK KRRQQ
Target Information
STK4 (MST1) is a serine/threonine kinase involved in apoptosis and chromatin condensation. It acts as a stress-activated, pro-apoptotic kinase that, upon caspase cleavage, translocates to the nucleus to induce chromatin condensation and DNA fragmentation.
STK4 is a core component of the Hippo signaling pathway, regulating organ size and tumor suppression by controlling cell proliferation and apoptosis. In this pathway, STK3/MST2 and STK4/MST1, together with SAV1, phosphorylate and activate LATS1/2–MOB1 complex, which in turn phosphorylates and inactivates YAP1 and WWTR1/TAZ.
Phosphorylation of YAP1 by LATS2 inhibits its nuclear translocation, thereby regulating genes involved in cell proliferation, death, and migration. STK3/MST2 and STK4/MST1 are essential for repressing hepatocyte proliferation, preventing activation of adult liver stem cells, and inhibiting tumor formation.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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