Thermo Fisher Scientific GDF6 Polyclonal Antibody

Applications and Tested Dilutions

Product Specifications

Product Specific Information

This antibody is predicted to react with bovine and rat based on sequence homology.

Target Information

GDF6 (Growth Differentiation Factor 6) is a member of the transforming growth factor (TGF) superfamily involved in embryonic development and adult tissue homeostasis. GDF6 and GDF7 are closely related to GDF5, which can induce activation of plasminogen activator and promote angiogenesis.
It is predominantly expressed in long bones during fetal development and plays a role in bone formation. In Xenopus, GDF6 is expressed at the edge of the neural plate and within the anterior neural plate, including the eye fields.
GDF6 is essential for normal formation of bones and joints in the limbs, skull, and axial skeleton, and may regulate ectodermal patterning via interactions with bone morphogenetic proteins (BMPs). It also contributes to eye development.
Mutations in this gene are associated with colobomata (ocular developmental abnormalities) and Klippel-Feil syndrome (KFS), a congenital disorder of spinal segmentation.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.