Thermo Fisher Scientific GDF6 Polyclonal Antibody
GDF6 단백질을 인식하는 Rabbit Polyclonal 항체로, Western blot, IHC, Flow Cytometry에 적합합니다. 인간 및 마우스에 반응하며, KLH 접합 합성 펩타이드로부터 유래되었습니다. 연구용으로만 사용 가능합니다.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:1,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:10–1:50 |
| Flow Cytometry (Flow) | 1:10–1:50 |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human, Mouse |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | KLH conjugated synthetic peptide between 326–353 amino acids from the C-terminal region of human GDF6 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Purification | Ammonium sulfate precipitation, Size-exclusion – Dialysis |
| Storage Buffer | PBS, pH 7.4 |
| Contains | 0.09% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2111240 |
Product Specific Information
This antibody is predicted to react with bovine and rat based on sequence homology.
Target Information
GDF6 (Growth Differentiation Factor 6) is a member of the transforming growth factor (TGF) superfamily involved in embryonic development and adult tissue homeostasis. GDF6 and GDF7 are closely related to GDF5, which can induce activation of plasminogen activator and promote angiogenesis.
It is predominantly expressed in long bones during fetal development and plays a role in bone formation. In Xenopus, GDF6 is expressed at the edge of the neural plate and within the anterior neural plate, including the eye fields.
GDF6 is essential for normal formation of bones and joints in the limbs, skull, and axial skeleton, and may regulate ectodermal patterning via interactions with bone morphogenetic proteins (BMPs). It also contributes to eye development.
Mutations in this gene are associated with colobomata (ocular developmental abnormalities) and Klippel-Feil syndrome (KFS), a congenital disorder of spinal segmentation.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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