Thermo Fisher Scientific BRE Polyclonal Antibody
인간 BRE/BRCC45 단백질을 인식하는 Thermo Fisher Scientific의 Rabbit Polyclonal Antibody. IHC 및 ICC/IF에 적합하며, 보존제가 없는 액상 형태. BRCA1/BRCA2 복합체 연구 및 DNA 손상 반응 관련 연구에 활용 가능.
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Thermo Fisher Scientific BRE Polyclonal Antibody
Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:500–1:2,000 |
| Immunocytochemistry (ICC/IF) | 1:200–1:1,000 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthetic peptide corresponding to the C-terminus of the Human BRCC45 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A, Antigen affinity chromatography |
| Storage Buffer | PBS |
| Contains | No preservative |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2788506 |
Product Specific Information
This product is preservative free. It is recommended to add sodium azide to avoid contamination (final concentration 0.05%–0.1%).
This antibody has specificity for Human BRE/BRCC45.
Target Information
BRCC45 was initially suggested to be a housekeeping protein highly expressed in brain and reproductive organs. Later experiments indicated BRCC45 forms a complex with BRCA1, BRCA2, RAD51, and BRCC36. This complex has ubiquitin E3 ligase activity and enhances cellular survival following DNA damage.
BRCC45 may also function as a death receptor–associated anti-apoptotic protein by inhibiting BID-induced activation of the mitochondrial apoptotic pathway. Higher levels of BRCC45 were detected in most hepatocellular carcinomas, suggesting its involvement in tumorigenesis when overexpressed.
At least three isoforms of BRCC45 are known to exist.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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