Thermo Fisher Scientific IL1A Monoclonal Antibody (1F3)
인간 IL-1α를 인식하는 Mouse IgG1 단클론 항체로, Western blot과 ELISA에 적합합니다. 친화 크로마토그래피로 정제되었으며 PBS(pH 7.4) 용액 형태로 제공됩니다. 염기성 사이토카인 연구 및 염증 반응 기전 분석에 유용합니다.
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Applications
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1–5 µg/mL |
| ELISA | 0.3 ng/mL |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1, kappa |
| Class | Monoclonal |
| Type | Antibody |
| Clone | 1F3 |
| Immunogen | IL1A (AAH13142, 172 a.a. – approximately 271 a.a.) partial recombinant protein with GST tag (GST tag MW: 26 kDa) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | See Label |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.4 |
| Contains | No preservative |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
Protein Sequence:
KSSKDDAKIT VILRISKTQL YVTAQDEDQP VLLKEMPEIP KTITGSETNL LFFWETHGTK NYFTSVAHPN LFIATKQDYW VCLAGGPPSI TDFQILENQA
Target Information
IL-1 alpha (Interleukin-1 alpha) is a proinflammatory cytokine expressed by monocytes, macrophages, and dendritic cells. It is encoded by the IL1A gene and signals through receptors IL-1RI and IL-1RII, which are shared with IL-1 beta.
IL1A is located on chromosome 2q13 and plays a key role in innate host defense by inducing production of other proinflammatory cytokines and initiating acute-phase responses.
IL-1 alpha activity is regulated by IL-1 Receptor Antagonist (IL-1RA), which inhibits receptor binding competitively.
This cytokine influences immune responses, inflammation, and hematopoiesis, and is produced as a proprotein that is processed and released upon cell injury to induce apoptosis.
High IL-1 alpha levels are associated with chronic inflammatory diseases such as rheumatoid arthritis, psoriasis, and multiple sclerosis.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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