Thermo Fisher Scientific Bcl-10 Monoclonal Antibody (4F8)
BCL-10 단백질 검출용 마우스 단클론 항체(4F8)로, WB, IHC, ICC, Flow, ELISA 등 다양한 응용에 적합합니다. 인간 및 마우스 시료에 반응하며, 비결합형 액상 형태로 제공됩니다. 연구용으로만 사용 가능합니다.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:2,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:200–1:1,000 |
| Immunocytochemistry (ICC/IF) | 1:200–1:1,000 |
| Flow Cytometry (Flow) | 1:200–1:400 |
| ELISA | 1:10,000 |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human, Mouse |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | 4F8 |
| Immunogen | Purified recombinant fragment of human BCL-10 expressed in E. coli |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | Not determined |
| Storage Buffer | Ascites |
| Contains | 0.03% sodium azide |
| Storage Conditions | Store at 4°C for short term. For long term, store at -20°C and avoid freeze/thaw cycles. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_10977153 |
Product Specific Information
MA5-14756 targets BCL-10 in indirect ELISA, FACS, IF, IHC, and WB applications and shows reactivity with human and mouse samples.
The immunogen is a purified recombinant fragment of human BCL-10 expressed in E. coli.
MA5-14756 detects BCL-10, which has a predicted molecular weight of approximately 26 kDa.
Target Information
BCL-10 is an N-terminal CARD (Caspase Recruitment Domain) containing protein involved in the adaptive immune response.
It promotes apoptosis, pro-caspase-9 maturation, and activation of NF-kappa-B via NIK and IKK pathways.
BCL-10 acts as an adapter protein between the upstream TNFR1-TRADD-RIP complex and the downstream NIK-IKK-IKAP complex.
It is a substrate for MALT1, and mutations in the gene are associated with Immunodeficiency 37 or mucosa-associated lymphoid type lymphoma.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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