Thermo Fisher Scientific CDK2 Monoclonal Antibody (OTI2A5), TrueMAB

Applications and Tested Dilutions

Product Specifications

Product Specific Information

For reconstitution, add 100 µL distilled water to obtain a final antibody concentration of approximately 1 mg/mL.
For conjugation experiments using this carrier-free antibody, perform an additional desalting step (recommended: Zeba Spin Desalting Columns, 7K MWCO, 0.5 mL, Product #89882).

Target Information

CDK2/cyclinO is a member of the cyclin-dependent protein kinase family complexed with CyclinO. CyclinO, a specific isoform of the UNG gene, is localized exclusively in the nucleus and exhibits uracil-DNA glycosylase activity.
CDK2/cyclinO protein levels increase during the G1 phase and are degraded during the cell cycle. Cyclin A–CDK2 levels peak at the G1/S transition, and both CDK2 and Cyclin A are associated with DNA in the initiation complex during replication.
Rb protein acts as a substrate for CDK2–Cyclin E and/or CDK2–Cyclin A in vivo. CDK2 is activated and localized to the nucleus during late G1-, S-, and G2-phase.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.