Thermo Fisher Scientific HSD11B2 Polyclonal Antibody
HSD11B2 단백질의 내인성 수준을 검출하는 Thermo Fisher Scientific의 폴리클로날 항체. 인간 시료에 반응하며 IHC(P) 등 다양한 응용 가능. 고순도 항원 친화 크로마토그래피 정제, 액상 형태로 제공. 연구용으로만 사용.
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Thermo Fisher Scientific HSD11B2 Polyclonal Antibody
Applications
- Immunohistochemistry (Paraffin) (IHC (P)): 1:50–1:200
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide corresponding to a region derived from internal residues of human hydroxysteroid (11-beta) dehydrogenase 2 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 2.9 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.4, with 40% glycerol |
| Contains | 0.05% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2636134 |
Product Specific Information
This antibody detects endogenous levels of total HSD11B2 protein.
Target Information
There are at least two isozymes of the corticosteroid 11-beta-dehydrogenase, a microsomal enzyme complex responsible for the interconversion of cortisol and cortisone.
The type I isozyme has both 11-beta-dehydrogenase (cortisol to cortisone) and 11-oxoreductase (cortisone to cortisol) activities.
The type II isozyme, encoded by this gene, has only 11-beta-dehydrogenase activity.
In aldosterone-selective epithelial tissues such as the kidney, the type II isozyme catalyzes the glucocorticoid cortisol to the inactive metabolite cortisone, preventing illicit activation of the mineralocorticoid receptor.
In tissues that do not express the mineralocorticoid receptor, such as the placenta and testis, it protects cells from the growth-inhibiting and/or pro-apoptotic effects of cortisol, particularly during embryonic development.
Mutations in this gene cause the syndrome of apparent mineralocorticoid excess and hypertension.
For Research Use Only.
Not for use in diagnostic procedures.
Not for resale without express authorization.
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