Thermo Fisher Scientific UBC13 Polyclonal Antibody
Human UBC13 단백질에 특이적인 염소 폴리클로날 항체로, Western blot, ELISA, Immunoprecipitation에 사용 가능. 친화 크로마토그래피로 정제된 액상 형태이며, 다양한 종에서 교차반응 가능. 연구용으로 DNA 손상 복구 및 세포 분화 연구에 적합.
- 카탈로그번호
- 600-101-342
- 판매단위
- pk
카탈로그
1개 옵션 · 카탈로그 번호를 클릭하면 복사됩니다Thermo Fisher Scientific · Thermo Fisher Scientific UBC13 Polyclonal Antibody
Thermo Fisher Scientific UBC13 Polyclonal Antibody
Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:5,000–1:10,000 |
| ELISA | 1:5,000–1:25,000 |
| Immunoprecipitation (IP) | 1:500–1:2,000 |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Goat / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | This affinity purified antibody was prepared from whole rabbit serum produced by repeated immunizations with a synthetic peptide corresponding to an internal region near amino acids 30–55 of human UBC13 protein. |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1.25 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | 0.02M potassium phosphate, pH 7.2, with 0.15M NaCl |
| Contains | 0.01% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
Store vial at -20°C prior to opening. Aliquot contents and freeze at -20°C or below for extended storage. Avoid cycles of freezing and thawing. Centrifuge product if not completely clear after standing at room temperature.
This product is stable for several weeks at 4°C as an undiluted liquid. Dilute only prior to immediate use.
This affinity-purified antibody is directed against human UBC13 protein. A BLAST analysis suggests cross-reactivity with UBC13 protein from various species including human, dog, bovine, Xenopus laevis, Xenopus tropicalis, zebrafish, rat, mouse, chimpanzee, macaque, and chicken based on 100% homology with the immunizing sequence. Reactivity against homologues from other sources is not known.
Target Information
The UBE2V1-UBE2N and UBE2V2-UBE2N heterodimers catalyze the synthesis of non-canonical Lys-63-linked polyubiquitin chains, which do not lead to protein degradation by the proteasome.
They mediate transcriptional activation of target genes and play roles in cell cycle control, differentiation, and error-free DNA repair.
These complexes act with E3 ligases (HLTF, SHPRH, RNF5, RNF135, and UB2V1) in Lys-63-linked polyubiquitination processes related to DNA repair, immune response, and inflammatory gene activation.
UBE2V1-UBE2N also participates in viral RNA-dependent polyubiquitination of RIG-I/DDX58 and TRAF6, contributing to interferon beta production and IL17A-mediated signaling.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
제품 이미지
Thermo Fisher Scientific 상품 둘러보기
전체보기
문의
0개 · 배송·재고 문의는 실시간 상담이 빠릅니다아직 등록된 문의가 없어요.