Thermo Fisher Scientific PLA2G2E Polyclonal Antibody

Applications and Tested Dilution

Product Specifications

Product Specific Information

This target displays homology in the following species:
Cow: 100%
Horse: 93%
Human: 100%
Mouse: 100%

Target Information

Secretory calcium-dependent phospholipase A2 that primarily targets extracellular phospholipids. Hydrolyzes the ester bond of the fatty acyl group attached at the sn-2 position of phospholipids, releasing various unsaturated fatty acids including oleoate, linoleoate, arachidonate, docosahexaenoate, and lysophosphatidylethanolamines in preference to lysophosphatidylcholines. In response to a high-fat diet, hydrolyzes minor lipoprotein phospholipids such as phosphatidylserines, phosphatidylinositols, and phosphatidylglycerols, altering lipoprotein composition and fat storage in adipose tissue and liver. May act in an autocrine and paracrine manner. Contributes to lipid remodeling of cellular membranes and generation of lipid mediators involved in pathogen clearance. Cleaves sn-2 fatty acyl chains of phosphatidylglycerols and phosphatidylethanolamines, which are major components of bacterial membrane phospholipids. Acts as a hair follicle phospholipase A2, selectively releasing lysophosphatidylethanolamines (LPE) and various unsaturated fatty acids in skin to regulate hair follicle homeostasis. May regulate the inflammatory response by releasing arachidonate, a precursor of prostaglandins and leukotrienes. Upon allergen exposure, may participate in allergic inflammatory response by enhancing leukotriene C4 synthesis and degranulation in mast cells. [UniProt]

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.