Thermo Fisher Scientific ALK Polyclonal Antibody
인간 ALK 단백질을 인식하는 염소 유래 다클론 항체로, IHC(P)에서 5–15 µg/mL 농도로 사용 가능. 뇌 발달 연구 및 ALK 관련 종양 연구에 적합. 액상 형태로 제공되며, -20°C에서 보관. 연구용으로만 사용.
- 카탈로그번호
- PA5142471
- 판매단위
- pk
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Applications and Tested Dilution
- Immunohistochemistry (Paraffin) (IHC (P)): 5–15 µg/mL
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Goat / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Peptide with sequence C-PTKKNNPIAKKEPH |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.5 mg/mL |
| Purification | Ammonium sulfate precipitation |
| Storage buffer | TBS, pH 7.3, with 0.5% BSA |
| Contains | 0.02% sodium azide |
| Storage conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping conditions | Wet ice |
| RRID | AB_2933119 |
Product Specific Information
This antibody is tested in Peptide ELISA: antibody detection limit dilution 1:32,000.
Target Information
Anaplastic Lymphoma Receptor Tyrosine Kinase (ALK) belongs to the insulin receptor superfamily and is vital for brain development.
Mutations, rearrangements, and amplifications in the ALK gene have been found in tumors such as anaplastic large cell lymphoma, neuroblastoma, and non-small cell lung cancer.
Chromosomal rearrangement is the most common genetic alteration, creating a fusion gene between ALK (chromosome 2) and NPM (chromosome 5), producing an oncogenic NPM-ALK fusion protein.
ALK encodes a receptor protein-tyrosine kinase with transmembrane and extracellular domains, showing high similarity to LTK.
It plays an important role in neural development and acts on specific neurons in the nervous system.
For Research Use Only.
Not for use in diagnostic procedures.
Not for resale without express authorization.
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