Thermo Fisher Scientific beta Catenin Recombinant Rabbit Monoclonal Antibody (BLR086G)
Thermo Fisher Scientific의 beta Catenin 재조합 토끼 단클론 항체(BLR086G)는 Western blot, IHC, ICC, Flow cytometry, IP 등 다양한 응용에 적합합니다. 인간 및 생쥐 반응성을 가지며, HEK293 세포에서 발현된 정제된 항체로 4°C에서 보관합니다.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:1,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:100 – 1:500 |
| Immunocytochemistry (ICC/IF) | 1:100 – 1:500 |
| Flow Cytometry (Flow) | 1 µL per 1 × 10⁶ cells |
| Immunoprecipitation (IP) | Assay-dependent |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human, Mouse |
| Host / Isotype | Rabbit / IgG |
| Expression System | HEK293 cells |
| Class | Recombinant Monoclonal |
| Type | Antibody |
| Clone | BLR086G |
| Immunogen | Peptide representing a region between residue 725 and 775 of human catenin beta 1 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 250 µg/mL |
| Purification | Purified |
| Storage Buffer | BBS, pH 7.8–8.6, with 0.1% BSA |
| Contains | 0.09% sodium azide |
| Storage Conditions | 4°C |
| Shipping Conditions | Wet ice |
Target Information
Beta-catenin is an adherens junction (AJ) protein originally identified as a component of cell-cell adhesion structures. AJs are essential for the creation and maintenance of epithelial cell layers by regulating cell growth and adhesion between cells. Beta-catenin interacts with the cytoplasmic domain of E-cadherin, linking it to alpha-catenin, which anchors the E-cadherin complex to the cortical actin cytoskeleton.
It also associates with cytoskeletal complexes containing adenomatous polyposis coli protein and microtubules, interacting with signaling pathways such as tyrosine kinases, phosphatases, and Wnt/Wingless. This interplay regulates morphogenesis. Beta-catenin is expressed in various hair follicle cell types, basal and peripheral matrix cells, and cells of the outer and inner root sheaths.
Pathological roles have been observed in pilomatrixoma, medulloblastoma, colorectal cancer, ovarian cancer, and tumor development. In the nucleus, beta-catenin co-activates Lef/Tcf transcription factors, stimulating transcription of genes like cyclin D and c-myc that promote cell proliferation, contributing to tumorigenesis in solid tumors of the breast, colon, liver, lung, gastric, prostate, and skin.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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