Thermo Fisher Scientific beta Catenin Recombinant Rabbit Monoclonal Antibody (BLR086G)

Applications and Tested Dilutions

Product Specifications

Target Information

Beta-catenin is an adherens junction (AJ) protein originally identified as a component of cell-cell adhesion structures. AJs are essential for the creation and maintenance of epithelial cell layers by regulating cell growth and adhesion between cells. Beta-catenin interacts with the cytoplasmic domain of E-cadherin, linking it to alpha-catenin, which anchors the E-cadherin complex to the cortical actin cytoskeleton.

It also associates with cytoskeletal complexes containing adenomatous polyposis coli protein and microtubules, interacting with signaling pathways such as tyrosine kinases, phosphatases, and Wnt/Wingless. This interplay regulates morphogenesis. Beta-catenin is expressed in various hair follicle cell types, basal and peripheral matrix cells, and cells of the outer and inner root sheaths.

Pathological roles have been observed in pilomatrixoma, medulloblastoma, colorectal cancer, ovarian cancer, and tumor development. In the nucleus, beta-catenin co-activates Lef/Tcf transcription factors, stimulating transcription of genes like cyclin D and c-myc that promote cell proliferation, contributing to tumorigenesis in solid tumors of the breast, colon, liver, lung, gastric, prostate, and skin.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.