Thermo Fisher Scientific BACE2 Polyclonal Antibody

Applications

Western Blot (WB)

• Tested Dilution: 2 µg/mL
• Publications: View 1 publication

Immunocytochemistry (ICC/IF)

• Tested Dilution: 1:10–1:200
• Publications: View reference

Product Specifications

Product Specific Information

PA1-753 detects human beta-secretase 2 (BACE2) from transfected cells and rat and mouse samples.
PA1-753 has been successfully used in Western blot and ICC/IF procedures.
By Western blot, this antibody detects an ~58 kDa protein representing BACE2 from SY-SY5Y cells overexpressing the human gene.
The PA1-753 immunizing peptide corresponds to amino acid residues 441–457 from human BACE2. This sequence is completely conserved in mouse.
The PA1-753 immunizing peptide (Cat. # PEP-166) is available for use in neutralization and control experiments.

Target Information

BACE2 (Beta Secretase 2) is responsible for the proteolytic processing of the amyloid precursor protein (APP).
BACE2 cleaves APP between residues 690 and 691, leading to the generation and extracellular release of beta-cleaved soluble APP.
It also cleaves APP between residues 671 and 672.
Accumulation of APP is a signature of Alzheimer’s disease and a frequent complication in adult Down syndrome patients.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.