Thermo Fisher Scientific Nemolizumab Humanized Recombinant Human Monoclonal Antibody

Applications

• ELISA (ELISA): Assay-dependent

Product Specifications

Product Specific Information

• Endotoxin level: < 0.01 EU/µg (LAL method)
• Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
• Store at 2–8°C for one week.
• Store at -20 to -80°C for twelve months from the date of receipt.

Target Information

Nemolizumab is a biosimilar that targets IL31RA.
IL-31 is a T cell cytokine preferentially produced by Th2 cells. It signals through a heterodimeric receptor composed of IL-31R and oncostatin M receptor (OSM). This receptor complex activates JAK1, JAK2, Stat1, Stat3, Stat5, and the PI3K/AKT cascade. SHP-2 and Shc adapter molecules contribute to MAP kinase pathway activation in response to IL-31.
Overexpression of IL-31 in mice leads to pruritus and dermatitis resembling human atopic dermatitis (AD). IL-31R expression is elevated in AD patient skin, and infiltrating cells express IL-31 mRNA. IL-31 may play a role in itch sensation and scratching behavior in atopic dermatitis models, representing a potential target for antipruritic drug development.

For Research Use Only.
Not for use in diagnostic procedures.
Not for resale without express authorization.